The International Agency for Research on Cancer (IARC) hosted a three-day meeting to launch the work of the European Commission Initiative on Gastric Cancer (EC-GaC) Working Group, part of the EU-GAINS project co-funded by the European Union (EU), on 19–21 January 2026. The EC-GaC Working Group is a multidisciplinary team composed of experts from various countries. Over the next 22 months and under the leadership and guidance of IARC and the European Commission’s Joint Research Centre (JRC), the Working Group will meet on several occasions to develop the first-ever evidence-based guidelines for Helicobacter pylori screen-and-treat strategies for gastric cancer prevention in Europe.