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Scientists from the International Agency for Research on Cancer (IARC) and partner institutions have uncovered novel insights into how acute and chronic exposures to arsenic, to smokeless tobacco, or to both together cause complex molecular and cellular changes associated with cancer hallmark processes. The study was published in the journal BioFactors.
The researchers conducted an integrative omics study in human oral cells and other models. They investigated the effects of arsenic and/or smokeless tobacco on the transcriptome and DNA methylome remodelling and analysed the impact on DNA and on oral cell health.
The resulting rich catalogue of molecular programmes in oral cells regulated by arsenic and smokeless tobacco exposure or co-exposure may provide the basis for future development of biomarkers for use in molecular cancer epidemiology studies of exposed populations at risk.
Das S, Thakur S, Cahais V, Virard F, Claeys L, Renard C, et al.,
Molecular and cell phenotype programs in oral epithelial cells directed by co-exposure to arsenic and smokeless tobacco
Biofactors. Published online 8 March 2025;
https://doi.org/10.1002/biof.70011
